Chipmunk singing sensations Alvin, Simon, and Theodore are back for an encore in this hilarious 'squeakquel' packed with more action and more nutty fun for the whole family. When a concert mishap lands Dave in the hospital, the Chipmunks take a break from superstardom and enroll in school to fit in with kids their age. But they soon face some stiff competition when they meet the Chipettes, a beautiful, talented trio of chipmunks.

Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital surgical unit. Alone in the world and unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.