Blythe Baxter has two amazing gifts: she can talk to animals and can create amazing fashion! Together with her pet friends, Zoe the spaniel, Pepper the skunk, Sunil the mongoose, Russell the hedgehog, Penny the panda, Vinnie the gecko, and Minka the monkey, Blythe is determined to make her dream of a career in fashion come true.

After losing his wife seven years earlier, the eccentric Dr. John Dolittle, famed doctor and veterinarian of Queen Victoria's England, hides behind the walls of Dolittle Manor with only his menagerie of exotic animals for company. But when the young queen falls gravely ill, a reluctant Dolittle is forced to set sail on an epic adventure to a mythical island in search of a cure. The doctor is joined on his quest by a young, self-appointed apprentice...

A 12-year-old tech prodigy's science experiment goes awry and he forges a telepathic connection with his best friend, his dog. The duo join forces and use their unique perspectives on life to comically overcome complications of family and school.