Narcotics cops Mike Lowrey and Marcus Bennett head up a task force investigating the flow of Ecstasy into Miami. Their search leads to a dangerous kingpin, whose plan to control the city's drug traffic has touched off an underground war. Meanwhile, things get sexy between Mike and Syd, Marcus' sister.

Marcus Burnett is now a police inspector and Mike Lowery is in a midlife crisis. They unite again when an Albanian mercenary, whose brother they killed, promises them an important bonus.