A woman stumbles upon a mysterious portal that links back to the Firstborn, omnipotent beings responsible for the upheaval of history and the creators of the notorious black monolith of "2001: A Space Odyssey."

Failing to eliminate life on Earth after their first attack, the Firstborn send a Q-bomb weapon to finish the job. Two cryogenically frozen females and a group of scientists studying the Eye, an artifact of the Firstborn, may be the only hope of finding a way to counter the onslaught.