In midcentury America, a team of young superheroes faces epic threats in public while battling personal demons behind closed doors.

Reed outfits a space shuttle, and the Fantastic Four use it to travel to the N-Zone, parallel universe experiencing heat death, an entropic state that signals the eventual end of that universe.

The adolescent assassin has left New York behind and set off to serve justice around the world. First stop: Colombia. A mother seeking vengeance for the murder of her child enlists Hit-Girl to destroy his killer, but Mindy has bigger plans for Palmira's most feared hitman. Armed to the hilt, Hit-Girl hijacks Fabio 'Mano' Mendoza and uses him to wipe out all local gangsters, before forcing him to turn his weapons on his own loved ones.

Is even an Omnibus big enough to contain Millar and Hitch's widescreen super hero epic?! They are the greatest heroes the world has ever known: Captain America, Iron Man, Thor, the Wasp, Giant Man, Hawkeye, the Black Widow, Quicksilver, and the Scarlet Witch! Brought together by Nick Fury, head of the elite espionage agency known as S.H.I.E.L.D., the Ultimates are Earth's last line of defense against a rising storm of strange new threats to humanity...