When middle-schooler Emily Elizabeth meets a magical animal rescuer who gifts her a little, red puppy, she never anticipated waking up to find a giant ten-foot hound in her small New York City apartment. While her single mom is away for business, Emily and her fun but impulsive uncle Casey set out on an adventure that will keep viewers on the edge-of-their-seats as the heroes take a bite out of the Big Apple.

Clifford learns what getting bigger is all about. Life lessons are more fun when you learn them with Clifford. Join in these adventures as Clifford and his friends get bigger and braver, and learn about new grown-up responsibilities.

Clifford's big doghouse is where the fun begins on Birdwell Island. It's the place where Clifford, Emily Elizabeth and their friends meet and make plans for adventures, both big and small. Laughing, playing and sharing great times together, they dig up treasures, perform in a band, explore the local carnival, and make a new friend.

T-Bone develops a crush on a visiting poodle named Mimi. Clifford works hard to try to make Emily the perfect Valentine.

While on his own, Clifford learns that playing by yourself can be fun, but being with friends is fun too. T-Bone learns that the support of good friends can help you manage feelings of fear.

The Howards do their best to make Clifford comfortable after he's grown too big for their city apartment. Jetta inadvertently gives Emily Elizabeth a sweater that was a gift from her grandma.

Clifford gets a bad case of the hiccups. When Jetta throws a "movie-watching" party, she expects everyone to do things her way which in this case means watching home movies of herself.

Emily is going off the island for a night and asks Charley to babysit Clifford. Fed up with his "responsibilities," Charley decides he would like to lead a dog's life.

In this flashback story, we learn how Emily and Clifford got together and how Emily's unconditional love changed the "runts" of the litter into the biggest dog around! This episode tells the story of the day the Howards moved to Birdwell Island.

Emily works hard to prepare for her audition for the lead in the school play, but loses the role to Jetta. Clifford is itching like crazy but tries his best to stop when he hears Emily say that she'll have to take him to the vet if he keeps it up.